If you're expecting the Bogart treatment: no. These ads ran in 1948, at the height of the Spade Craze. People were just mad for Sam's adventures, because they were amusing and literate.

Wikipedia: "The Adventures of Sam Spade, Detective was a radio series based loosely on the private detective character Sam Spade, created by writer Dashiell Hammett for The Maltese Falcon. The show ran for 13 episodes on ABC in 1946, for 157 episodes on CBS in 1946-1949, and finally for 51 episodes on NBC in 1949-1951. The series starred Howard Duff (and later, Steve Dunne) as Sam Spade and Lurene Tuttle as his secretary Effie, and took a considerably more tongue-in-cheek approach to the character than the novel or movie. The announcer was Dick Joy."

For a year or so Sam solved crimes for Wildroot in the Sunday comics, and Effie was usually tagging along.

This is one of the rare instances of a hard-boiled detective subduing a suspect by throwing a bottle of hair-oil cream at his head.

The tube wouldn't have incapacitated him. Spade would have had to shoot him. I don't remember radio Spade doing much gat-work, though.